AN ASYMMETRIC APPROACH TO THE PYRROLIZIDINE RING-SYSTEM VIA N-ACETYL AND N-PROPIONYL ANION CYCLIZATION PROCESSES

被引：29

作者：

MURRAY, A

PROCTOR, GR

MURRAY, PJ

机构：

[1] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,GLASGOW G1 1XL,LANARK,SCOTLAND

[2] GLAXO RES & DEV LTD,WARE SG12 0DP,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02233-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient route to the pyrrolizidine ring system has been developed. The method, which uses N-acetyl and N-propionyl anion cyclisation reactions as the key steps has provided the natural pyrrolizidines (-)-(1R,8S)-1-hydroxy-pyrrolizidine (10), (-)-pyrrolizidin-1-ene-3-one (13), (+/-)-trachelanthamidine (18) together with a range of 2-methyl substituted pyrrolizidine-3-ones.

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页码：291 / 294

页数：4

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