BENIGN PROSTATIC HYPERTROPHY AFFECTS THE ENDOTHELIN RECEPTOR DENSITY IN THE HUMAN URINARY-BLADDER AND PROSTATE

被引：26

作者：

KONDO, S

MORITA, T

TASHIMA, Y

机构：

[1] Second Department of Biochemistry, Akita University School of Medicine, Akita

[2] Department of Urology, Tokyo Medical and Dental University School of Medicine, Tokyo

来源：

UROLOGIA INTERNATIONALIS | 1995年 / 54卷 / 04期

关键词：

ENDOTHELIN RECEPTOR; ENDOTHELIN ISOFORMS; URINARY BLADDER; PROSTATE; BENIGN PROSTATIC HYPERTROPHY;

D O I：

10.1159/000282723

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of benign prostatic hypertrophy (BPH) on the endothelin (ET) receptor density in the lower urinary tract tissues were studied using radioligand binding techniques. Saturation experiments revealed that there were significant amounts of the binding sites for the ET isoforms (ET-1, -2, -3) in the human bladder and prostate in both prostate hypertrophy (PH) and nonhypertrophy (NPH) patients. Autoradiograms of hypertrophic adenoma showed that ET-1 receptors were localized in both the stromal and glandular tissue. In the bladder and the prostate, the KD values were not significantly different between the PH and NPH groups. In the bladder dome, the B-max, values of I-125-ET-1, -2 and -3 decreased significantly in the PH groups, while, in the adenoma, they increased significantly in the PH group. BPH was found to affect the ET receptor density in both the bladder and the prostate. These data suggest that ETs are involved in the pathophysiology of BPH.

引用

页码：198 / 203

页数：6

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