THE RELATIONSHIP OF TAP1 AND TAP2 DIMORPHISMS TO MULTIPLE-SCLEROSIS SUSCEPTIBILITY

被引：7

作者：

BELL, RB

RAMACHANDRAN, S

机构：

[1] UNIV CALGARY,FAC MED,HLTH SCI CTR,DEPT IMMUNOL,CALGARY,AB T2N 4N1,CANADA

[2] UNIV CALGARY,FAC MED,HLTH SCI CTR,GENET RES GRP,CALGARY,AB T2N 4N1,CANADA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 59卷 / 1-2期

关键词：

MULTIPLE SCLEROSIS; SUSCEPTIBILITY; TAP GENES;

D O I：

10.1016/0165-5728(95)00046-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transporters associated with antigen processing and presentation (TAP1 and TAP2) have been considered candidate genes in MS susceptibility based on evidence from experimental animal models confirming antigenic peptide selection by transporter polymorphisms and by the proximity of these transporter genes to the DR- and DQ-associated alleles known to confer disease risk in man. We report here an association study examining the influence of TAP gene polymorphisms on MS susceptibility in a Canadian patient population. Our results do not support a role for the five polymorphisms examined in the etiology of this disease.

引用

页码：201 / 204

页数：4

共 20 条

[1] MULTIPLE-SCLEROSIS - AN AUTOIMMUNE-DISEASE OF MULTIFACTORIAL ETIOLOGY [J].