EFFECTIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF GLAFENINE IN PLASMA - PHARMACOKINETIC APPLICATION

被引：3

作者：

ENNACHACHIBI, A ^{[1
]}

NICOLAS, P ^{[1
]}

FAUVELLE, F ^{[1
]}

PERRET, G ^{[1
]}

PETITJEAN, O ^{[1
]}

机构：

[1] CHU BOBIGNY, PHARMACOL CLIN EXPTL LAB, F-93000 BOBIGNY, FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1988年 / 427卷 / 02期

关键词：

D O I：

10.1016/0378-4347(88)80133-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method for an effective determination of glafenine and its main metabolite, glafenic acid, is described. The assay involved separate extraction procedures for glafenine and for its metabolite, but the same internal standard (floctafenine) and the same chromatographic conditions (including a 5-.mu.m C8 column, a quaternary solvent mixture of water-acetonitrile-diethylamine-acetic acid and an ultraviolet detector set at 360 nm). For 1 ml of plasma, the detection limit is 0.05 mg/l for glafenine and 0.25 mg/l for glafenic acid. Compared with previously described techniques, this assay uses a very low glafenine linearity range, which allows the true pharmacokinetics of this drug to be described for the first time.

引用

页码：307 / 314

页数：8

共 12 条

[1] DAUDON M, 1983, ANN BIOL CLIN-PARIS, V41, P105
[2] GAULTIER M, 1974, THERAPIE, V29, P579
[3] MALLEIN R, 1976, THERAPIE, V31, P739
[4] MONTAGNAC R, 1982, CONCOURS MED, V104, P1341
[5] BIOPHARMACEUTICS OF RECTAL ADMINISTRATION OF DRUGS IN MAN - ABSORPTION RATE AND BIOAVAILABILITY OF GLAFENINE AFTER ORAL AND RECTAL ADMINISTRATION
MOOLENAAR, F
VISSER, J
HUIZINGA, T
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1980, 4 (03) : 195 - 203
[6] PARAF A, 1965, CLINIQUE, V40, P690
[7] PETERFALVI M, 1966, MED PHARMACOL EXP, V15, P254
[8] PHAF C, 1973, CLIN TRIALS J, V4, P125
[9] POTTIER J, 1979, EUR J DRUG METAB PH, V2, P109
[10] Rondelet J, 1966, Therapie, V21, P1573

← 1 2 →