ISOLATION AND PRIMARY STRUCTURE OF A NOVEL CHROMOGRANIN-A-DERIVED PEPTIDE, WE-14, FROM A HUMAN MIDGUT CARCINOID-TUMOR

被引：53

作者：

CURRY, WJ ^{[1
]}

SHAW, C ^{[1
]}

JOHNSTON, CF ^{[1
]}

THIM, L ^{[1
]}

BUCHANAN, KD ^{[1
]}

机构：

[1] NOVO NORDISK A-S,BAGSVAERD,DENMARK

来源：

FEBS LETTERS | 1992年 / 301卷 / 03期

关键词：

CHROMOGRANIN-A; WE-14; SEQUENCE ANALYSIS; HUMAN;

D O I：

10.1016/0014-5793(92)80266-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The primary structure of a novel human chromogranin A-derived tetradecapeptide, WE-14, possessing N-terminal tryptophanyl (W) and C-terminal glutamyl (E) residues was isolated from a hepatic metastasis of an human ileal carcinoid tumour. Human and bovine WE-14 are structurally identical, while rat, mouse and porcine analogues exhibit 93% homology. WE-14 is flanked by paired basic residues (KR) in all known chromogranin A sequences.

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页码：319 / 321

页数：3

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