A MULTICENTER ASSESSMENT OF THE SPECIFICITY OF 10 ANTI-HBC SCREENING-TESTS

被引：25

作者：

HUGHES, W

BARR, A

DOW, BC

FOLLETT, EAC

BARBARA, JAJ

机构：

[1] RUCHILL HOSP,REG VIRUS LAB,SNBTS MICROBIOL REFERENCE UNIT,GLASGOW G20 9NB,LANARK,SCOTLAND

[2] LAW HOSP,GLASGOW & W SCOTLAND BLOOD TRANSFUS SERV,CARLUKE ML8 5ES,SCOTLAND

[3] N LONDON BLOOD TRANSFUS CTR,LONDON NW9 5BG,ENGLAND

来源：

TRANSFUSION MEDICINE | 1995年 / 5卷 / 03期

关键词：

ANTI-HBC; DONATIONS; SCREENING; SPECIFICITY;

D O I：

10.1111/j.1365-3148.1995.tb00232.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Samples from 1828 donations were screened for anti-HBc at seven sites in the UK using kits supplied by 10 manufacturers. Only 10 (0.55%) donations were considered to have true anti-HBc reactivity and these were detected by all 10 kits. Additional markers of HBV infection were found in nine of these 10 donations. Additional reactives were found by all kits, the number ranging from 1 to 43. In the four more specific kits, the 10 true reactives were clearly distinguished from the 'false reactives' by the strength of the reaction. It is concluded that the reliance on a single ELISA test for anti-HBc diagnosis is unwise. The use of a second test known to be more specific than the screening ELISA is recommended.

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页码：225 / 230

页数：6

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