EVIDENCE FOR INTERACTION OF DIFFERENT EUKARYOTIC TRANSCRIPTIONAL ACTIVATORS WITH DISTINCT CELLULAR TARGETS

被引：220

作者：

MARTIN, KJ ^{[1
]}

LILLIE, JW ^{[1
]}

GREEN, MR ^{[1
]}

机构：

[1] HARVARD UNIV, DEPT BIOCHEM & MOLEC BIOL, CAMBRIDGE, MA 02138 USA

来源：

NATURE | 1990年 / 346卷 / 6280期

关键词：

D O I：

10.1038/346147a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The adenovirus E1a protein (E1a), a potent transcription activator, contains a transcriptional activating region. Compared with previously described cellular and viral activators, E1a's activating region has unusual structural properties. It seems that E1a's activating region interacts with a cellular target not required for the function of transcriptional activators with 'acidic' activating regions. By contrast, the target of an acidic activating region is required both by acidic activators and by E1a. It is proposed that the cellular target of E1a's activating region is an 'adaptor' that allows E1a to interact with the basic transcriptional machinery. © 1990 Nature Publishing Group.

引用

页码：147 / 152

页数：6

共 42 条

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