BENZYLOXAZOLIDINE-2,4-DIONES AS POTENT HYPOGLYCEMIC AGENTS

被引：84

作者：

DOW, RL

BECHLE, BM

CHOU, TT

CLARK, DA

HULIN, B

STEVENSON, RW

机构：

[1] Central Research Division, Pfizer Incorporated, Groton

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 05期

关键词：

D O I：

10.1021/jm00109a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

引用

页码：1538 / 1544

页数：7

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