THE ORGANIZATION OF THE MOUSE SECRETOGRANIN-II GENE

被引：45

作者：

SCHIMMEL, A

BRAUNLING, O

RUTHER, U

HUTTNER, WB

GERDES, HH

机构：

[1] UNIV HEIDELBERG,INST NEUROBIOL,IM NEUENHEIMER FELD 364,W-6900 HEIDELBERG,GERMANY

[2] EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1992年 / 314卷 / 03期

关键词：

GRANINS; SECRETOGRANIN; GENE STRUCTURE; NEUROSECRETORY VESICLE; TRANSCRIPTION FACTOR; EVOLUTION;

D O I：

10.1016/0014-5793(92)81509-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have characterized the gene which encodes mouse secretogranin II (previously also referred to as chromogranin C), a tyrosine-sulfated secretory protein belonging to the granin (chromogranin/secretogranin) family which is found in secretory granules of most endocrine cells and neurons. The secretogranin II gene was found to contain 2 exons. In contrast to chromogranin A and chromogranin B, the two previously characterized granin genes, the entire secretogranin II protein is encoded by a single exon, exon 2, with exon 1 containing only a 5'-untranslated sequence. Consistent with previous data on the expression of secretogranin II, the putative promoter region was found to contain a cAMP-responsive element and a potential AP-1 binding site.

引用

页码：375 / 380

页数：6

共 19 条

[1] THE PRIMARY STRUCTURE OF BOVINE CHROMOGRANIN-A - A REPRESENTATIVE OF A CLASS OF ACIDIC SECRETORY PROTEINS COMMON TO A VARIETY OF PEPTIDERGIC CELLS [J].