INTRACISTERNAL INJECTION OF PANCREATIC-POLYPEPTIDE STIMULATES GASTRIC-EMPTYING IN RATS

被引：22

作者：

OKUMURA, T

PAPPAS, TN

TAYLOR, IL

机构：

[1] DUKE UNIV,MED CTR,DEPT SURG,DURHAM,NC 27710

[2] VET ADM MED CTR,DURHAM,NC 27710

[3] MED UNIV S CAROLINA,DEPT MED,CHARLESTON,SC 29425

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 01期

关键词：

CENTRAL NERVOUS SYSTEM; GASTRIC EMPTYING; PANCREATIC POLYPEPTIDE; VAGOTOMY;

D O I：

10.1016/0304-3940(94)90316-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, we evaluated the effects of central administration of pancreatic polypeptide (PP) on gastric emptying of a liquid meal in conscious rats using a phenol red method. Intracisternal injection of PP (0.5-2.0 mu g) speeds gastric emptying of a test meal in a dose-dependent manner. In contrast, i.p. injection of PP al the same doses inhibited gastric emptying in a dose-related fashion. Bilateral gastric branch vagotomy abolished the increase in gastric emptying evoked by intracisternal PP. These results demonstrate that PP speeds gastric emptying through the vagal system when given centrally but slows emptying when given peripherally.

引用

页码：167 / 170

页数：4

共 24 条

[1] PANCREATIC-POLYPEPTIDE IMMUNOREACTIVITY IN RAT-BRAIN IS ACTUALLY NEUROPEPTIDE-Y [J].