DIHYDROPYRIDINES ON GUINEA-PIG ILEUM

被引：5

作者：

MARTIN, I

COLADO, I

DELVAL, V

ALFARO, MJ

机构：

[1] Department of Pharmacology, School of Medicine, Universidad Complutense

来源：

GENERAL PHARMACOLOGY | 1990年 / 21卷 / 01期

关键词：

D O I：

10.1016/0306-3623(90)90592-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 μM) and high-K (50 mM). 3. 3. From these experiments it is concluded that nimodipine and nitrendipine, like nifedipine, produced a similar and potent inhibitory effect of the contractile responses induced in the guinea-pig ileum. 4. 4. Nisoldipine resulted to be the most active agent. © 1990.

引用

页码：41 / 44

页数：4

共 23 条

[1]

AMBACHE N, 1954, J PHYSIOL-LONDON, V125, P53

[2] THE EFFECT OF NIFEDIPINE AND VERAPAMIL ON THE PENDULAR MOVEMENTS OF THE RABBIT ISOLATED ILEUM [J].