THE ELASTIC-MODULUS OF FIBRIN CLOTS AND FIBRINOGEN GELS - THE EFFECT OF FIBRONECTIN AND DITHIOTHREITOL

被引：11

作者：

PROCYK, R ^{[1
]}

KING, RG ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, DEPT PHYSIOL, NEW YORK, NY 10032 USA

来源：

BIOPOLYMERS | 1990年 / 29卷 / 03期

关键词：

D O I：

10.1002/bip.360290311

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The elastic modulus (G′) of factor XIIIa induced fibrinogen gels was found to be substantially lower than the G′ of fibrin gels that were formed by clotting fibrinogen with thrombin. The addition of fibronectin and/or the reducing reagent dithiothreitol (DTT) to the factor XIIIa coagulation mixture led to the formation of a weaker gel structure, while the rigidity of thrombin induced clots was not appreciably affected by the inclusion of the DTT but increased somewhat in the presence of fibronectin. The reasons for the differing clot rigidities are discussed in terms of biochemical mechanisms. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：559 / 565

页数：7

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