ANTIDIABETIC SULFONYLUREAS RELAX ISOLATED RABBIT CORONARY-ARTERIES

被引：11

作者：

NIELSENKUDSK, JE

THIRSTRUP, S

机构：

[1] Institute of Pharmacology, University of Aarhus, DK-8000 Aarhus C, The Bartholin Building

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 03期

关键词：

SULFONYLUREAS; GLIBENCLAMIDE; CROMAKALIM; K+ CHANNELS; CORONARY ARTERY; SMOOTH MUSCLE;

D O I：

10.1016/0014-2999(91)90182-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antidiabetic sulfonylureas completely relaxed isolated rabbit coronary arteries contracted by prostaglandin F2-alpha. The order of potency was glibenclamide (EC50 = 4.75-mu-M) > glipizide = glibornuride = tolbutamide = chlorpropamide. The drugs also relaxed the contractions induced by 30 mM K+ but much less potently. The effectiveness of the drugs as vascular smooth muscle relaxants did not correlate with their ability to antagonize the vasorelaxant action of cromakalim. Sulfonylurea-induced vasorelaxation probably involves mechanisms other than an interaction with ATP-regulated K+ channels.

引用

页码：273 / 275

页数：3

共 10 条

[1]

BRAYDEN JE, 1991, BLOOD VESSELS, V28, P147

[2] GLIBENCLAMIDE IS A COMPETITIVE ANTAGONIST OF THE THROMBOXANE A2 RECEPTOR IN DOG CORONARY-ARTERY INVITRO [J].