LYMPH-NODE METASTASES VERSUS DNA PLOIDY AS PROGNOSTIC FACTORS FOR INVASIVE DUCTAL CARCINOMA OF THE BREAST

被引:13
作者
NOGUCHI, M
TANIYA, T
OHTA, N
KOYASAKI, N
MIYAZAKI, I
MIZUKAMI, Y
机构
[1] KANAZAWA UNIV HOSP,SCH MED,DEPT SURG 2,KANAZAWA 920,JAPAN
[2] KANAZAWA UNIV HOSP,SCH MED,PATHOL SECT,KANAZAWA 920,JAPAN
关键词
PROGNOSTIC FACTOR; LYMPH NODE METASTASES; DNA PLOIDY; BREAST CANCER; INTERNAL MAMMARY NODAL STATUS;
D O I
10.1007/BF01975201
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We evaluated the relationship between the DNA ploidy status and other variable prognostic factors, especially regional lymph node metastases, in 121 patients with invasive ductal carcinoma of breast, together with the value of these factors in estimating the prognosis of breast cancer. The ploidy status was diploid in 40% of the patients, and aneuploid in 60%. A significantly higher incidence of aneuploidy was found in patients with more than 4 positive axillary lymph nodes, positive internal mammary lymph nodes, or clinical stage 3 of malignancy. In a univariate study, overall survival and disease-free survival were significantly correlated with axillary and internal mammary lymph node metastases, tumor size, and clinical stage of malignancy. The disease-free survival rates for the diploid group tended to be somewhat higher than those for the aneuploid group of patients without axillary lymph node metastases. In the multivariate analysis, however, only axillary lymph node metastasis was significantly correlated with overall survival and disease-free survival. There was also a trend for the internal mammary lymph node metastases to be correlated with survival. As the DNA ploidy status was closely correlated with the axillary and internal mammary lymph node metastases, it did not appear to be an independent prognostic factor in this small series.
引用
收藏
页码:23 / 31
页数:9
相关论文
共 38 条
[1]   PROGNOSTIC-SIGNIFICANCE OF DNA-PLOIDY IN A SERIES OF 690 PRIMARY BREAST-CANCER PATIENTS [J].
BEERMAN, H ;
KLUIN, PM ;
HERMANS, J ;
VANDEVELDE, CJH ;
CORNELISSE, CJ .
INTERNATIONAL JOURNAL OF CANCER, 1990, 45 (01) :34-39
[2]   PREDICTION OF RELAPSE OR SURVIVAL IN PATIENTS WITH NODE-NEGATIVE BREAST-CANCER BY DNA FLOW-CYTOMETRY [J].
CLARK, GM ;
DRESSLER, LG ;
OWENS, MA ;
POUNDS, G ;
OLDAKER, T ;
MCGUIRE, WL .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (10) :627-633
[3]   DNA PLOIDY AND SURVIVAL IN BREAST-CANCER PATIENTS [J].
CORNELISSE, CJ ;
VANDEVELDE, CJH ;
CASPERS, RJC ;
MOOLENAAR, AJ ;
HERMANS, J .
CYTOMETRY, 1987, 8 (02) :225-234
[4]   DEOXYRIBONUCLEIC-ACID (DNA) CONTENT OF CARCINOMAS AND PROGNOSIS IN HUMAN-BREAST CANCER [J].
DESHPANDE, N ;
MITCHELL, I ;
ALLEN, D ;
MILLIS, R .
INTERNATIONAL JOURNAL OF CANCER, 1983, 32 (06) :693-696
[5]  
DEVITA V, 1989, NEW ENGL J MED, V8, P527
[6]   FLOW-CYTOMETRIC DNA ANALYSIS IN PRIMARY BREAST CARCINOMAS AND CLINICOPATHOLOGICAL CORRELATIONS [J].
EWERS, SB ;
LANGSTROM, E ;
BALDETORP, B ;
KILLANDER, D .
CYTOMETRY, 1984, 5 (04) :408-419
[7]   FLOW-CYTOMETRY DNA PLOIDY AND NUMBER OF CELL-POPULATIONS IN THE PRIMARY BREAST-CANCER AND THEIR CORRELATION TO THE PROGNOSIS [J].
EWERS, SB ;
BALDETORP, B ;
KILLANDER, D ;
LANGSTROM, E .
ACTA ONCOLOGICA, 1989, 28 (06) :913-918
[8]   THE REVOLUTION IN BREAST-CANCER SURGERY - SCIENCE OR ANECDOTALISM [J].
FISHER, B .
WORLD JOURNAL OF SURGERY, 1985, 9 (05) :655-666
[9]  
FOSSA SD, 1984, ACTA PATH MICRO IM A, V92, P475
[10]   METHOD FOR ANALYSIS OF CELLULAR DNA CONTENT OF PARAFFIN-EMBEDDED PATHOLOGICAL MATERIAL USING FLOW-CYTOMETRY [J].
HEDLEY, DW ;
FRIEDLANDER, ML ;
TAYLOR, IW ;
RUGG, CA ;
MUSGROVE, EA .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1983, 31 (11) :1333-1335