INTRAVENOUS TISSUE PLASMINOGEN-ACTIVATOR FOR THE TREATMENT OF ACUTE THROMBOEMBOLIC ISCHEMIA

被引:23
作者
HENNERICI, M
HACKE, W
VONKUMMER, R
HORNIG, C
ZANGEMEISTER, W
机构
[1] UNIV DUSSELDORF,DEPT NEUROL,W-4000 DUSSELDORF 1,GERMANY
[2] UNIV GIESSEN,DEPT NEUROL,W-6300 GIESSEN,GERMANY
关键词
THROMBOLYSIS; STROKE; PLASMINOGEN ACTIVATOR;
D O I
10.1159/000108907
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Eighteen patients were treated with 70 mg tissue plasminogen activator (t-PA) intravenously after the onset of acute severe cerebral ischemia: 10 suffered from vertebrobasilar occlusive disease and 8 had carotid territory strokes. In the former, reperfusion rates were poor (4/10) which was associated with a fatal clinical outcome in 7. In patients with internal carotid and middle cerebral artery occlusions, reperfusion rates were similarly low (3/7), 3 patients died from ischemia independent from the observed perfusional state and 1 suffered a fatal hemorrhage after infusion of less than 25 mg t-PA. Since many of the patients particularly with vertebrobasilar disease were somnolent or stuporous, an unfavorable delay between thrombosis and thrombolysis was suggested - in addition, since infarction was obvious on CT. In all, the dosage selected seemed to be too low to be efficient. Further investigations are required to test the benefit of earlier treatment (< 4 h) with higher dosages of t-PA.
引用
收藏
页码:124 / 128
页数:5
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