DOUBLE-BLIND TRIAL OF DEXAMETHASONE VERSUS METHYLPREDNISOLONE IN MULTIPLE-SCLEROSIS ACUTE RELAPSES

被引：49

作者：

LAMANTIA, L

EOLI, M

MILANESE, C

SALMAGGI, A

DUFOUR, A

TORRI, V

机构：

[1] NATL INST NEUROL C BESTA,DEPT CLIN INVEST,MILAN,ITALY

[2] MARIO NEGRI INST PHARMACOL RES,I-20157 MILAN,ITALY

来源：

EUROPEAN NEUROLOGY | 1994年 / 34卷 / 04期

关键词：

MULTIPLE SCLEROSIS; RELAPSE; STEROIDS;

D O I：

10.1159/000117038

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The efficacy of dexamethasone (DX) and methylprednisolone (MP) at high (HD) and low (LD) dose in acute multiple sclerosis (MS) relapses was evaluated by a double-blind trial in 31 patients followed for 1 year. DX and HDMP were similarly efficacious in promoting recovery, while LDMP was ineffective in the short-term outcome and was followed by an early clinical reactivation. The different outcomes seem to be related to different immunomodulating effects, mainly on cerebrospinal fluid (CSF) IgG synthesis and on peripheral blood and CSF CD4(+) lymphocyte subsets.

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页码：199 / 203

页数：5

相关论文

共 21 条

[1] INTRAVENOUS METHYLPREDNISOLONE FOR MULTIPLE-SCLEROSIS IN RELAPSE [J].

BARNES, MP ;

BATEMAN, DE ;

CLELAND, PG ;

DICK, DJ ;

WALLS, TJ ;

NEWMAN, PK ;

SAUNDERS, M ;

TILLEY, PJB .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1985, 48 (02) :157-159

[2] THE EFFECT OF CORTICOSTEROIDS FOR ACUTE OPTIC NEURITIS ON THE SUBSEQUENT DEVELOPMENT OF MULTIPLE-SCLEROSIS [J].

BECK, RW ;

CLEARY, PA ;

TROBE, JD ;

KAUFMAN, DI ;

KUPERSMITH, MJ ;

PATY, DW ;

BROWN, CH .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (24) :1764-1769

[3] A RANDOMIZED, CONTROLLED TRIAL OF CORTICOSTEROIDS IN THE TREATMENT OF ACUTE OPTIC NEURITIS [J].

BECK, RW ;

CLEARY, PA ;

ANDERSON, MM ;

KELTNER, JL ;

SHULTS, WT ;

KAUFMAN, DI ;

BUCKLEY, EG ;

CORBETT, JJ ;

KUPERSMITH, MJ ;

MILLER, NR ;

SAVINO, PJ ;

GUY, JR ;

TROBE, JD ;

MCCRARY, JA ;

SMITH, CH ;

CHROUSOS, GA ;

THOMPSON, HS ;

KATZ, BJ ;

BRODSKY, MC ;

GOODWIN, JA ;

ATWELL, CW .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (09) :581-588

[4]

CERRATO D, 1984, ITAL J NEUROL SCI, V3, P303

[5] A DOUBLE-BLIND CONTROLLED TRIAL OF HIGH-DOSE METHYLPREDNISOLONE IN PATIENTS WITH MULTIPLE-SCLEROSIS .2. LABORATORY RESULTS [J].

COMPSTON, DAS ;

MILLIGAN, NM ;

HUGHES, PJ ;

GIBBS, J ;

MCBROOM, V ;

MORGAN, BP ;

CAMPBELL, AK .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1987, 50 (05) :517-522

[6] HIGH-DOSE INTRAVENOUS METHYLPREDNISOLONE IN THE TREATMENT OF MULTIPLE-SCLEROSIS - CLINICAL-IMMUNOLOGICAL CORRELATIONS [J].

DURELLI, L ;

COCITO, D ;

RICCIO, A ;

BARILE, C ;

BERGAMASCO, B ;

BAGGIO, GF ;

PERLA, F ;

DELSEDIME, M ;

GUSMAROLI, G ;

BERGAMINI, L .

NEUROLOGY, 1986, 36 (02) :238-243

[7] CD8+ HIGH CD11B+ LOW T-CELLS (T-SUPPRESSOR-EFFECTORS) IN MULTIPLE-SCLEROSIS CEREBROSPINAL-FLUID ARE INCREASED DURING HIGH-DOSE CORTICOSTEROID TREATMENT [J].

DURELLI, L ;

POCCARDI, G ;

CAVALLO, R .

JOURNAL OF NEUROIMMUNOLOGY, 1991, 31 (03) :221-228

[8]

FREY BM, 1984, J IMMUNOL, V133, P2479

[9] EXACERBATION RATES AND ADHERENCE TO DISEASE TYPE IN A PROSPECTIVELY FOLLOWED-UP POPULATION WITH MULTIPLE-SCLEROSIS - IMPLICATIONS FOR CLINICAL-TRIALS [J].

GOODKIN, DE ;

HERTSGAARD, D ;

RUDICK, RA .

ARCHIVES OF NEUROLOGY, 1989, 46 (10) :1107-1112

[10]

HAYNES RC, 1986, PHARM BASIC THERAPEU, P1431