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EXACERBATION OF ASTHMA AFTER PYRIDOSTIGMINE DURING OPERATION DESERT-STORM
被引：13
作者：
GOUGE, SF
DANIELS, DJ
SMITH, CE
机构：
[1] Nephrology Service, Department of Medicine, Brooke Army Medical Center, San Antonio
关键词：
D O I：
10.1093/milmed/159.2.108
中图分类号：
R5 [内科学];
学科分类号：
1002 ;
100201 ;
摘要：
Pyridostigmine was first used extensively during Operation Desert Storm for prophylaxis against the effects of nerve agents. After initial reports of asthma exacerbations following its use, we gave 10 asthmatic and 6 non-asthmatic soldiers a 30-mg dose of pyridostigmine. We found no changes in forced vital capacity in any of the soldiers, but observed exacerbation of asthma symptoms in seven of the asthmatics. Severity of the exacerbation correlated best with severity of asthma in the desert and inversely with body weight. The irritant effect of the dust may predispose asthmatics to worsen after pyridostigmine, an effect not seen in the laboratory.
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页码：108 / 111
页数：4
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