EFFECT OF THE SULFONYLUREA GLYBURIDE ON GLYCOGEN-SYNTHASE ACTIVITY IN ALLOXAN-INDUCED DIABETIC RAT ADIPOCYTES

被引：3

作者：

ALTAN, N

ATALAY, T

ONGUN, CO

机构：

[1] Department of Biochemistry, Faculty of Medicine, University of Gazi, 06510 Beşevler, Ankara

来源：

GENERAL PHARMACOLOGY | 1994年 / 25卷 / 06期

关键词：

GLYBURIDE; GLYCOGEN SYNTHASE; DIABETES MELLITUS;

D O I：

10.1016/0306-3623(94)90144-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effect of glyburide (glibenclamide) treatment in vivo on the adipose tissue glycogen synthase activity of type II diabetic rats has been studied. 2. Three week treatment of diabetic animals with glyburide (5 mg/kg orally, in saline) increased adipose glycogen synthase activity and decreased blood glucose levels. 3. These results demonstrate that the sulfonylurea glyburide is capable of exerting direct insulin-like effect on adipose glycogen-synthase activity of type II diabetic rats in vivo.

引用

页码：1245 / 1247

页数：3

共 24 条

[1] INSULIN-LIKE AND INSULIN-ENHANCING EFFECTS OF THE SULFONYLUREA GLYBURIDE ON RAT ADIPOSE GLYCOGEN-SYNTHASE [J].