CHANGES OF ALDOLASE-A AND ALDOLASE-B MESSENGER-RNA LEVELS IN RAT-LIVER DURING AZO-DYE-INDUCED HEPATOCARCINOGENESIS

被引：12

作者：

DAIMON, M ^{[1
]}

TSUTSUMI, K ^{[1
]}

SATO, J ^{[1
]}

TSUTSUMI, R ^{[1
]}

ISHIKAWA, K ^{[1
]}

机构：

[1] YAMAGATA UNIV, SCH MED, DEPT BIOCHEM, YAMAGATA 99023, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1984年 / 124卷 / 02期

关键词：

D O I：

10.1016/0006-291X(84)91558-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of aldolase A and B mRNAs during azo-dye-induced carcinogenesis in rat liver was examined. After feeding the dye for 18 wk, the level of aldolase A mRNA increased to about 11 times that in a normal liver, with the concomitant decrease of aldolase B mRNA level to about 25% of that in a normal liver. These changes did not occur progressively during the carcinogenesis, but occurred as an additional phase after 4 wk-feeding of the azo-dye. At this stage, the levels of aldolase A and B mRNAs were about 7 times and 45% of that in a normal liver, respectively. This biphasic pattern in the aldolase isozyme expression in the azo-dye-fed rat liver is discussed together with the kinetic data of the enzyme activity.

引用

页码：337 / 343

页数：7

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