NOVEL GLUTAMATE RECEPTOR ANTAGONISTS SELECTIVELY PROTECT AGAINST KAINIC ACID NEUROTOXICITY IN CULTURED CEREBRAL-CORTEX NEURONS

被引：38

作者：

FRANDSEN, A ^{[1
]}

KROGSGAARDLARSEN, P ^{[1
]}

SCHOUSBOE, A ^{[1
]}

机构：

[1] ROYAL DANISH SCH PHARM,DEPT ORGAN CHEM,DK-2100 COPENHAGEN,DENMARK

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 05期

关键词：

Cultured neurons; Excitatory amino acids; Glutamate; Neurotoxicity; Non‐N‐methyl‐d‐aspartate antagonists;

D O I：

10.1111/j.1471-4159.1990.tb04976.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: The effect on excitatory amino acid (EAA)‐induced toxicity of two novel non‐N‐methyl‐d‐aspartate (non‐NMDA) antagonists 2‐amino‐3‐[3‐(carboxymethoxy)‐5‐methylisoxazol‐4‐yl]propionic acid (AMOA) and 2‐amino‐3‐[2‐(3‐hydroxy‐5‐methyl‐isoxazol‐4‐yl)methyl‐5‐methyl‐3‐oxoisoxazolin‐4‐yl]propionic acid (AMNH) was tested in primary cultures of cerebral cortex neurons. Such cultures provide a useful model for the investigation of the toxicity of EAAs and a convenient screening system for potential neuroprotective activity of pharmacological agents. It was demonstrated that AMNH and AMOA abolished neurotoxicity induced by kainic acid with IC50 values of 62 ± 10 and 120 ± 19 μM, respectively. No effect on neuronal damage induced by NMDA or AMPA could be detected. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1821 / 1823

页数：3

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