ROLE OF VASCULAR FACTORS, INCLUDING ANGIOGENESIS, IN THE MECHANISMS OF ACTION OF SUCRALFATE

被引:71
作者
SZABO, S
VATTAY, P
SCARBROUGH, E
FOLKMAN, J
机构
[1] CHILDRENS HOSP MED CTR,DEPT SURG,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115
关键词
D O I
10.1016/0002-9343(91)90469-E
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This brief overview of our recent results implicates vascular factors in the mechanisms of acute and chronic actions of sucralfate. Pretreatment of rats with sucralfate and its components, such as SOS and sodium sulfate, prevented the ethanol-induced microvascular injury and maintained blood flow in the gastric mucosa. Thus, preservation of microvascular integrity seems to be one of the mechanisms of acute gastroprotection by sucralfate. Chronic experiments with subcutaneously implanted sponges containing sucralfate or SOS revealed that both compounds stimulated angiogenesis, whereas only sucralfate enhanced the area of granulation tissue. These processes may have a role in the ulcer-healing action of sucralfate.
引用
收藏
页码:S158 / S160
页数:3
相关论文
共 12 条
[1]  
FOLKMAN J, 1990, Journal of Cell Biology, V111, p223A
[2]  
HOLLANDER D, 1989, NEW PHARM ULCER DISE, P404
[3]  
LACY ER, 1984, LAB INVEST, V51, P573
[4]  
NAGASHIMA R, 1983, SCAND J GASTROENTERO, V18, P17
[5]   EARLY MICROCIRCULATORY STASIS IN ACUTE GASTRIC-MUCOSAL INJURY IN THE RAT AND PREVENTION BY 16,16-DIMETHYL PROSTAGLANDIN-E2 OR SODIUM THIOSULFATE [J].
PIHAN, G ;
MAJZOUBI, D ;
HAUDENSCHILD, C ;
TRIER, JS ;
SZABO, S .
GASTROENTEROLOGY, 1986, 91 (06) :1415-1426
[6]  
ROBERT A, 1989, ULCER DISEASE NEW AS, P417
[7]  
SZABO S, 1989, ACTA PHYSIOL HUNG, V73, P115
[8]  
SZABO S, 1987, P SOC EXP BIOL MED, V185, P493
[9]   PATHWAYS OF GASTROINTESTINAL PROTECTION AND REPAIR - MECHANISMS OF ACTION OF SUCRALFATE [J].
SZABO, S ;
HOLLANDER, D .
AMERICAN JOURNAL OF MEDICINE, 1989, 86 (6A) :23-31
[10]   EARLY VASCULAR INJURY AND INCREASED VASCULAR-PERMEABILITY IN GASTRIC-MUCOSAL INJURY CAUSED BY ETHANOL IN THE RAT [J].
SZABO, S ;
TRIER, JS ;
BROWN, A ;
SCHNOOR, J .
GASTROENTEROLOGY, 1985, 88 (01) :228-236