SELENIUM IN HUMAN MAMMARY CARCINOGENESIS - A CASE-COHORT STUDY

被引:32
作者
OVERVAD, K
WANG, DY
OLSEN, J
ALLEN, DS
THORLING, EB
BULBROOK, RD
HAYWARD, JL
机构
[1] IMPERIAL CANC RES FUND, DEPT CLIN ENDOCRINOL, LONDON WC2A 3PX, ENGLAND
[2] AARHUS KOMMUNE HOSP, DANISH CANC SOC, DEPT NUTR & CANC, DK-8000 AARHUS, DENMARK
[3] GUYS HOSP, BREAST UNIT, LONDON SE1 9RT, ENGLAND
关键词
D O I
10.1016/0277-5379(91)90143-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In a prospective study conducted on the island of Guernsey a cohort of 5162 ostensibly healthy women was enrolled between 1967 and 1976. Blood samples were drawn from each participant, who also completed a questionnaire, which provided information on established risk indicators in human mammary carcinogenesis. Plasma selenium levels were measured in 46 breast cancer cases diagnosed a mean of 11 (S.D. 4) years after entry into the study cohort and in an age-stratified sample of 138 women drawn from the study base. Plasma selenium level in the cases was 109 (28)-mu-g/l and in the base sample 103 (22)-mu-g/l (95% confidence interval for the overall difference, -2 to 14-mu-g/1). The adjusted relative risk of developing breast cancer in the different quartiles of the selenium distribution was 0.80, 0.79, 0.72 and 1.00, respectively. Thus, in the present study selenium was not a strong indicator of human breast cancer risk.
引用
收藏
页码:900 / 902
页数:3
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