A SEROTONIN AGONIST PHASE-SHIFTS THE CIRCADIAN CLOCK IN THE SUPRACHIASMATIC NUCLEI INVITRO

被引:145
作者
PROSSER, RA
MILLER, JD
HELLER, HC
机构
[1] Department of Biological Sciences, Stanford University, Stanford
关键词
Brain slice; Circadian clock; Oscillator; Quipazine; Serotonin; Suprachiasmatic nucleus;
D O I
10.1016/0006-8993(90)90153-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The mammalian circadian pacemaker in the suprachiasmatic nuclei (SCN) receives a large serotonergic (5-HTergic) projection from the raphe nuclei. Whether the SCN pacemaker can be modulated by this afferent projection is a question of considerable theoretical and practical interest. In this study we investigated whether the 5-HT agonist, quipazine, can reset the phase of the SCN clock when it is isolated in vitro. Our results show that 1 h treatments with quipqzine induce robust phase shifts in vitro, and that this effect depends upon the circadain time of treatment. We further show that the ability of quipazine to induce phase shifts is dose-dependent. These results suggest that the SCN circadian pacemaker is sensitive to 5-HTergic stimulation, and therefore that the 5-HTergic projection to the SCN may play a role in modulating the phase of the SCN clock in the intact animal. © 1990.
引用
收藏
页码:336 / 339
页数:4
相关论文
共 34 条
[1]   ELECTRON MICROSCOPY OF DEGENERATION WITHIN SEROTONIN PATHWAY OF RAT BRAIN [J].
AGHAJANIAN, GK ;
BLOOM, FE ;
SHEARD, MH .
BRAIN RESEARCH, 1969, 13 (02) :266-+
[2]   EFFECT OF MIDBRAIN RAPHE NUCLEI LESIONS ON CIRCADIAN-RHYTHM OF PLASMA CORTICOSTERONE IN RAT [J].
BALESTRERY, FG ;
MOBERG, GP .
BRAIN RESEARCH, 1976, 118 (03) :503-508
[3]   FURTHER-STUDIES ON CIRCADIAN HORMONE RHYTHMS AFTER LOCAL PHARMACOLOGICAL DESTRUCTION OF THE SEROTONINERGIC INNERVATION OF THE RAT SUPRACHIASMATIC REGION BEFORE THE ONSET OF THE CORTICOSTERONE RHYTHM [J].
BANKY, Z ;
MOLNAR, J ;
CSERNUS, V ;
HALASZ, B .
BRAIN RESEARCH, 1988, 445 (02) :222-227
[4]   CIRCADIAN-RHYTHMS OF RAT LOCOMOTOR ACTIVITY AFTER LESIONS OF MIDBRAIN RAPHE NUCLEI [J].
BLOCK, M ;
ZUCKER, I .
JOURNAL OF COMPARATIVE PHYSIOLOGY, 1976, 109 (03) :235-247
[5]   THE GASTROINTESTINAL PROKINETIC BENZAMIDE DERIVATIVES ARE AGONISTS AT THE NON-CLASSICAL 5-HT RECEPTOR (5-HT4) POSITIVELY COUPLED TO ADENYLATE-CYCLASE IN NEURONS [J].
DUMUIS, A ;
SEBBEN, M ;
BOCKAERT, J .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1989, 340 (04) :403-410
[6]   CIRCADIAN-RHYTHMS OF VASOPRESSIN RELEASE FROM INDIVIDUAL RAT SUPRACHIASMATIC EXPLANTS INVITRO [J].
EARNEST, DJ ;
SLADEK, C .
BRAIN RESEARCH, 1986, 382 (01) :129-133
[7]  
EDGAR DM, 1990, P SOC RES BIOL RHYTH, V2, P80
[8]  
EDGAR DM, 1988, P SOC RES BIOL RHYTH, V53
[9]   VOLTAMMETRIC MEASUREMENTS OF 5-HYDROXYINDOLE COMPOUNDS IN THE SUPRACHIASMATIC NUCLEI - CIRCADIAN FLUCTUATIONS [J].
FARADJI, H ;
CESPUGLIO, R ;
JOUVET, M .
BRAIN RESEARCH, 1983, 279 (1-2) :111-119
[10]   THE HYPOTHALAMIC SUPRACHIASMATIC NUCLEI - CIRCADIAN PATTERNS OF VASOPRESSIN SECRETION AND NEURONAL-ACTIVITY INVITRO [J].
GILLETTE, MU ;
REPPERT, SM .
BRAIN RESEARCH BULLETIN, 1987, 19 (01) :135-139