EVALUATION OF POLYALKYLCYANOACRYLATE NANOPARTICLES AS A POTENTIAL-DRUG CARRIER - PREPARATION, MORPHOLOGICAL CHARACTERIZATION AND LOADING CAPACITY

被引：13

作者：

PUGLISI, G

GIAMMONA, G

FRESTA, M

CARLISI, B

MICALI, N

VILLARI, A

机构：

[1] Istituto di Chimica Farmaceutica e Tossicologica, Universita di Catania, 95125, Catania, V. le A. Doria

[2] Dipartimento di Chimica e Tecnologie Farmaceutiche, Universita di Palermo, 90125, Palermo

[3] Istituto Tecniche Spettroscopiche CNR Messina, Salita Sperone 31 villagio S. Agata, 98166, Messina

[4] Dipartimento Farmaco-Chimico, Università di Messina, 98010, Messina, V. le Annunziata

来源：

JOURNAL OF MICROENCAPSULATION | 1993年 / 10卷 / 03期

关键词：

D O I：

10.3109/02652049309031525

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Some physicochemical behaviours were investigated of polyethyl- (PECA) and polyisobutylcyanoacrylate (PICA), which, in recent years, have been proposed as nanoparticle colloidal systems for drug carrying. We observed the influence of preparation conditions, such as pH value and surfactant concentration, on parameters such as particle size and polymer molecular weight. Lower operating pH values (0-2) resulted in smaller nanoparticles than those prepared at pH 5.5. The polymer molecular weight was also a function of pH: low molecular weight at low pH and vice-versa. The surfactant concentration positively influenced main particle size and polymer molecular weight. These trends were independent of type of monomer; in fact, both ethyl- (ECA) and isobutyl-2-cyanoacrylate (ICA) showed the same behaviour. Loading capacity, as well as release profile, of the two polymers were evaluated using fluorescein as a model drug. Whereas both polymers showed almost the same release profile, there was a difference in the amount of encapsulated probe: higher aliquots for PICA than for PECA. Storage effects on such physicochemical parameters were also tested.

引用

页码：353 / 366

页数：14

共 25 条

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