A DITERPENE FROM MIKANIA-OBTUSATA ACTIVE ON TRYPANOSOMA-CRUZI

被引：60

作者：

ALVES, TMA

CHAVES, PPG

SANTOS, LMST

NAGEM, TJ

MURTA, SMF

CERAVOLO, IP

ROMANHA, AJ

ZANI, CL

机构：

[1] FIOCRUZ MS,CTR PESQUISAS RENE RACHOU,QUIM PROD NAT LAB,BR-30190002 BELO HORIZONT,MG,BRAZIL

[2] UNIV FED MINAS GERAIS,ICEX,DEPT QUIM,BELO HORIZONT,MG,BRAZIL

[3] FIOCRUZ MS,CTR PESQUISAS RENE RACHOU,PARASITOL CELULAR & MOLEC LAB,BR-30190002 BELO HORIZONT,MG,BRAZIL

来源：

PLANTA MEDICA | 1995年 / 61卷 / 01期

关键词：

D O I：

10.1055/s-2006-958011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The diterpene ent-kaur-16-en-19-oic acid (1) was identified as the trypanocidal component of the ethanolic extract from Mikania obtusata D. C. (Asteraceae). This compound presents an IC50 Of 0.5 mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).

引用

页码：85 / 87

页数：3

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