DEVELOPMENTAL-CHANGES IN BRAIN ANGIOTENSIN-II RECEPTORS IN THE RAT

被引：33

作者：

MILLAN, MA ^{[1
]}

KISS, A ^{[1
]}

AGUILERA, G ^{[1
]}

机构：

[1] NICHHD, DEV ENDOCRINOL BRANCH, ENDOCRINE PHYSIOL SECT, 10 RM 10N262, BETHESDA, MD 20892 USA

来源：

PEPTIDES | 1991年 / 12卷 / 04期

关键词：

ANGIOTENSIN-II; BRAIN RECEPTORS; DEVELOPMENT;

D O I：

10.1016/0196-9781(91)90125-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All binding and distribution were measured in rat brain during development by autoradiographic techniques using radioiodinated [Sar1, Ile8]AII. At all ages, from 2 days to 7 weeks, binding was present in the circumventricular organs, and areas related to pituitary hormone secretion and modulation of sympathetic activity. At early stages of development, AII binding was transiently expressed in a number of motor- and sensory-related areas. These findings support a role for AII in the control of water intake and autonomic activity at all stages of development, and suggest that the peptide may be involved in the maturation of neuronal function during development.

引用

页码：723 / 737

页数：15

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