NOTE ON LINKAGE ANALYSIS WHEN THE MODE OF TRANSMISSION IS UNKNOWN

被引：6

作者：

NEUMAN, RJ

RICE, JP

机构：

[1] WASHINGTON UNIV,SCH MED,DIV BIOSTAT,ST LOUIS,MO 63110

[2] JEWISH HOSP ST LOUIS,ST LOUIS,MO 63110

来源：

GENETIC EPIDEMIOLOGY | 1990年 / 7卷 / 05期

关键词：

ascertainment correction; genetic parameters; lod score; maximum likelihood;

D O I：

10.1002/gepi.1370070505

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A major difficulty in a linkage analysis arises from the necessity of specifying the mode of inheritance prior to analysis. For a complex disease, such as those encountered in psychiatric illnesses, the mode of inheritance is generally not known in advance. Consequently, some estimation procedure is often combined with linkage analysis to circumvent this. We discuss several precautions that should be taken when using traditional statistical testing methods: correction of the likelihood for the method of sampling families and the computation of the lod score. We analyze simulated data with pedigrees selected under a sampling scheme approximating single ascertainment. In this situation, the severity of the above problems is attenuated. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：349 / 358

页数：10