DISSEMINATED INTRAVASCULAR COAGULATION IN NEUROSURGICAL PATIENTS - DIAGNOSIS BY NEW LABORATORY METHODS

被引:11
作者
BREDBACKA, S
BLOMBACK, M
WIMAN, B
PELZER, H
机构
[1] KAROLINSKA HOSP,DEPT CLIN CHEM & BLOOD COAGULAT,S-10401 STOCKHOLM 60,SWEDEN
[2] BEHRINGWERKE AG,DEPT BLOOD COAGULATION,W-3550 MARBURG,GERMANY
关键词
DISSEMINATED INTRAVASCULAR COAGULATION; BRAIN TRAUMA; BLOOD COAGULATION; FIBRINOLYSIS; MULTIPLE ORGAN FAILURE; SOLUBLE FIBRIN; THROMBIN-ANTITHROMBIN COMPLEXES; PROTHROMBIN FRAGMENT 1 + 2;
D O I
10.1097/00008506-199204000-00008
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Disseminated intravascular coagulation (DIC) constitutes a part of the multiple organ failure (MOF) syndrome seen with such disorders as trauma and sepsis. Early detection of increased coagulation and fibrinolytic activity is important. The dynamic changes in some markers for early detection of the activation of these cascade systems are presented in relation to two patients with brain trauma. The clinical status and the severity of the disease were assessed by an established scoring method (APACHE II). The coagulation activation was noted by the appearance of increased end products of the coagulation cascade, such as soluble fibrin, thrombin-antithrombin complex, and prothrombin fragment 1 + 2. Fibrinolytic activation and an increased secondary inhibition of fibrinolysis were detected by increased levels of D-dimer and plasminogen activator inhibitor-1. Leukocyte activation was indicated by a rise in elastase. The laboratory results normalized with clinical improvement. These new methods seem to detect DIC earlier than traditional methods and may also be of value for monitoring treatment.
引用
收藏
页码:128 / 133
页数:6
相关论文
共 14 条
  • [1] ANTITHROMBIN (HEPARIN COFACTOR) ASSAY WITH NEW CHROMOGENIC SUBSTRATES (S-2238 AND CHROMOZYM-TH)
    ABILDGAARD, U
    LIE, M
    ODEGARD, OR
    [J]. THROMBOSIS RESEARCH, 1977, 11 (04) : 549 - 553
  • [2] EVIDENCE FOR A RAPID INHIBITOR TO TISSUE PLASMINOGEN-ACTIVATOR IN PLASMA
    CHMIELEWSKA, J
    RANBY, M
    WIMAN, B
    [J]. THROMBOSIS RESEARCH, 1983, 31 (03) : 427 - 436
  • [3] ELMS MJ, 1983, THROMB HAEMOSTASIS, V50, P591
  • [4] HEHNE HJ, 1976, EUR J INTEN CARE MED, V2, P157
  • [5] JENNET B, 1982, MANAGEMENT HEAD INJU, P233
  • [6] KAUFMAN HH, 1985, CENTRAL NERVOUS SYST, P187
  • [7] APACHE-II - A SEVERITY OF DISEASE CLASSIFICATION-SYSTEM
    KNAUS, WA
    DRAPER, EA
    WAGNER, DP
    ZIMMERMAN, JE
    [J]. CRITICAL CARE MEDICINE, 1985, 13 (10) : 818 - 829
  • [8] MAMMEN EF, 1988, DISSEMINATED INTRAVA, P299
  • [9] MAMMEN EF, 1989, DISSEMINATED INTRAVA, V2, P1
  • [10] NEUMANN S, 1984, J CLIN CHEM CLIN BIO, V22, P693