POLAROGRAPHIC-DETERMINATION OF CLAVULANIC ACID

被引：10

作者：

PEREZ, CG

MARTIN, IG

DEALDANA, BRV

机构：

[1] Departamento de Química Analitica, Nutricion y Bromatología, Facultad de Química, Universidad de Salamanca

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 05期

关键词：

DIFFERENTIAL-PULSE POLAROGRAPHY; CLAVULANIC ACID;

D O I：

10.1016/0731-7085(91)80161-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method is proposed for the determination of clavulanic acid by differential pulse polarography. The electroactive product was obtained by hydrolysis in sulphuric medium. It shows a reduction peak, that can be used analytically, at -0.75 V (vs SCE). The optimum conditions for the polarographic signal were determined and a study was made of the different parameters affecting the electrochemical process. A polarographic procedure is proposed for the determination of clavulanic acid in a concentration range of 8.0 x 10(-6) - 1.4 x 10(-4) M. The detection limit is about 2 x 10(-6) M and the relative standard deviation is 1.1%. The method was applied to the determination of clavulanic acid in the presence of amoxicillin.

引用

页码：383 / 386

页数：4

共 15 条

[1] SPECTROPHOTOMETRIC ASSAY OF CLAVULANIC ACID BY REACTION WITH IMIDAZOLE [J].