EFFECTS OF STEROID-HORMONES AND IMMUNOSUPPRESSANT DRUGS ON DEFENSES AGAINST UTERINE MICROBIAL-CONTAMINATION IN THE RAT

被引：2

作者：

GARD, PR

FAWCETT, JP

KERR, KP

NEALE, TJ

机构：

[1] UNIV OTAGO,WELLINGTON SCH MED,WELLINGTON,NEW ZEALAND

[2] CENT INST TECHNOL,SCH PHARM,WELLINGTON,NEW ZEALAND

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1992年 / 34卷 / 01期

关键词：

IMMUNOSUPPRESSIVE AGENTS; ADNEXITIS; UTERUS;

D O I：

10.1159/000292721

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This study used rats as a mammalian model to investigate the effects of steroid hormones and immunosuppressant drugs on uterine microflora. It was shown that prednisolone acetate predisposed to uterine contamination unlike oestradiol, ciclosporin and cyclophosphamide. It therefore appears that the leucocyte component of the immune system does not normally play a role in preventing bacterial colonization of the uterus and that prednisolone is producing its effect via some other mechanism, possibly an effect on cervical mucus.

引用

页码：31 / 35

页数：5

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