SIMULTANEOUS DETERMINATION OF AMOXICILLIN AND DICLOXACILLIN IN CAPSULES BY POTENTIOMETRIC TITRIMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Direct potentiometric titration and two HPLC conditions for the simultaneous determination of amoxycillin and dicloxacillin in their capsules have been developed. One-run titration utilizing 0.05M acet. HClO4 enables the quantification of both antibiotics. The HPLC-separation could be undertaken on reversed phase, LiChrosorb RP-18 (10 mum), and LiChrospher 100 RP-18 (5 mum), columns by using mobile phases containing acetonitrile + 1% aq, acetic acid, in proportions of 47:53 or 39:61 (v/v), respectively, at a flow rate of 1.5 ml/min with UV-detection at 240 nm. Recoveries of the individual drugs by the application of each described method were found to be fairly satisfactory.