INHIBITION OF CAFFEINE METABOLISM BY CIPROFLOXACIN IN CHILDREN WITH CYSTIC-FIBROSIS AS MEASURED BY THE CAFFEINE BREATH TEST

被引：30

作者：

PARKER, AC

PRESTON, T

HEAF, D

KITTERINGHAM, NR

CHOONARA, I

机构：

[1] ALDER HEY CHILDRENS HOSP,INST CHILD HLTH,LIVERPOOL L12 2AP,MERSEYSIDE,ENGLAND

[2] SCOTTISH UNIV RES & REACTOR CTR,E KILBRIDE,LANARK,SCOTLAND

[3] ALDER HEY CHILDRENS HOSP,RESP UNIT,LIVERPOOL L12 2AP,MERSEYSIDE,ENGLAND

[4] UNIV LIVERPOOL,DEPT PHARMACOL,LIVERPOOL,MERSEYSIDE,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 38卷 / 06期

关键词：

CAFFEINE BREATH TEST; CHILDREN; CIPROFLOXACIN; CYSTIC FIBROSIS;

D O I：

10.1111/j.1365-2125.1994.tb04399.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The caffeine breath test was carried out in six children with cystic fibrosis, before and during a course of ciprofloxacin. There was a significant decrease in the 2 h cumulative labelled CO2 exhaled during ciprofloxacin treatment, mean difference (s.d.) -5.2(3.3)%, P < 0.02. The results suggest an inhibition of 3-N-demethylation of caffeine (CYP1A2 enzyme activity) by ciprofloxacin. Ciprofloxacin may cause significant drug interactions in children with cystic fibrosis. The caffeine breath test can be used to study drug interactions involving CYP1A2 in children.

引用

页码：573 / 576

页数：4

共 14 条

[1] HUMAN CYTOCHROME P-450PA (P-450IA2), THE PHENACETIN O-DEETHYLASE, IS PRIMARILY RESPONSIBLE FOR THE HEPATIC 3-DEMETHYLATION OF CAFFEINE AND N-OXIDATION OF CARCINOGENIC ARYLAMINES - (AROMATIC-AMINES HETEROCYCLIC AMINES CARCINOGEN METABOLISM) [J].