A PROSPECTIVE-STUDY OF THE VALUE OF MAMMOGRAPHIC PATTERNS AS INDICATORS OF BREAST-CANCER RISK IN A SCREENING EXPERIENCE

被引：53

作者：

CIATTO, S

ZAPPA, M

机构：

[1] Centro per lo Studio e la Prevenzione Oncologica, I-50131 Florence

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 1993年 / 17卷 / 02期

关键词：

BREAST; NEOPLASMS; RADIOGRAPHY; PARENCHYMAL PATTERN; BREAST NEOPLASM;

D O I：

10.1016/0720-048X(93)90048-R

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The association between mammographic parenchymal patterns and the risk of subsequent breast cancer was studied in a cohort of 17 911 women aged 40-70 years, enrolled in a mammographic screening program. The cohort was prospectively followed-up for 5 years after blind attribution of mammographic pattern. Incident cancers, either screen- or interval-detected, were monitored through the screening program and by the local cancer registry. Multivariate analysis adjusting for the confounding effect of age, demonstrated an independent and significant association between mammograpic patterns and breast cancer risk. The relative risk of subsequent breast cancer, assumed to be 1 for N1 pattern, was 2.39 (1.0-5.7) for P1, 4.02 (1.7-9.3) for P2, and 5.01 (1.9-13.3) for DY category, respectively. The relative risk of P2-DY with respect to N1-P1 categories was 2.09 (1.4-3.1). A diagnostic delay, possibly due to the 'masking effect' of a radiologically dense breast, was evident for P2-DY with respect to N1-P1 cancers (proportion of Stage I cancers = 42% vs. 69%). These results suggest the adoption of a shorter rescreening interval in P2-DY subjects.

引用

页码：122 / 125

页数：4

共 23 条

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