THE ATP-DEPENDENT POTASSIUM CHANNEL - AN ENDOGENOUS CARDIOPROTECTIVE MECHANISM

被引:37
作者
YAO, ZH
GROSS, GJ
机构
关键词
MYOCARDIAL INFARCT SIZE; ISCHEMIC PRECONDITIONING; ADENOSINE; ACETYLCHOLINE; ATP-DEPENDENT POTASSIUM CHANNEL;
D O I
10.1097/00005344-199424014-00005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The major objectives of the present study were to examine the effects of ischemic preconditioning and two endogenous substances, adenosine and acetylcholine (ACh), on myocardial infarct size to determine the role of the cardiac K-ATP channel in mediating these effects. Barbital-anesthetized open-chest dogs subjected to 60 min of left anterior descending coronary artery (LAD) occlusion followed by 4 h of reperfusion were used. Preconditioning elicited by 10 min of LAD occlusion or intracoronary infusion of adenosine (400 mu g/min) or ACh (10 mu g/min) for 10 min, followed by 10 min of reperfusion or drug-free period before the 60-min occlusion period, markedly reduced myocardial infarct size to a similar extent compared to that in control dogs that were infused with an equivalent volume of saline into the LAD for 10 min followed by a 10-min saline-free period before the 60-min ischemic insult. The infarct size-limiting effects of these three endogenous interventions were totally abolished by the specific K-ATP-channel blockers glibenclamide or 5-hydroxydecanoate. These results indicate that cardiac K-ATP-channel activation is an important endogenous protectant against ischemia-reperfusion injury.
引用
收藏
页码:S28 / S34
页数:7
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