PHYSICOCHEMICAL ANALYSIS OF THE FACTORS GOVERNING DISTRIBUTION OF SOLUTES BETWEEN BLOOD AND BRAIN

被引：32

作者：

CHADHA, HS

ABRAHAM, MH

MITCHELL, RC

机构：

[1] UNIV LONDON UNIV COLL,DEPT CHEM,LONDON WC1H 0AJ,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)80274-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An equation is described that relates the equilibrium distribution of compounds between blood and brain to various solute descriptors, for 57 varied compounds. It is shown that the main factors influencing the distribution are solute size that favours brain, and solute dipolarity/ polarisability, hydrogen-bond acidity and hydrogen-bond basicity that favour blood. The descriptors can be obtained from measurements on compound substructures, so that the blood-brain distribution can be predicted for drug molecules without the necessity for synthesis.

引用

页码：2511 / 2516

页数：6

共 18 条

[1] HYDROGEN-BONDING .21. SOLVATION PARAMETERS FOR ALKYLAROMATIC HYDROCARBONS FROM GAS-LIQUID-CHROMATOGRAPHIC DATA [J].