EXTRACELLULAR ATP PROMOTES CELLULAR GROWTH OF GLOMERULAR MESANGIAL CELLS MEDIATED VIA PHOSPHOLIPASE-C

被引：27

作者：

ISHIKAWA, S

KAWASUMI, M

KUSAKA, I

KOMATSU, N

IWAO, N

SAITO, T

机构：

[1] JICHI MED SCH,DIV METAB,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[2] JICHI MED SCH,DIV HEMATOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[3] JICHI MED SCH,DEPT MED,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1917

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study was undertaken to determine whether extracellular ATP promotes cellular growth of glomerular mesangial cells. ATP increased inositol 1,4,5-trisphosphate (IP3) production and cellular free calcium concentration ([Ca2+](i)) in a dose-dependent manner. None of ADP, AMP or adenosine caused an increase in IP3 production or [Ca2+](i) mobilization. Also, ATP activated mitogen-activated protein (MAP)kinase and H-3-thymidine incorporation and increased the absorbance by colorimetric assay in a dose-dependent manner. Again, either of ADP, AMP or adenosine had no effect. These results indicate that extracellular ATP binds to P-2 purinergic receptors and activates phospholipase C in glomerular mesangial cells. Such a signal transduction promotes cellular growth of mesangium. (C) 1994 Academic Press, Inc.

引用

页码：234 / 240

页数：7

共 22 条

[1] EFFECT OF EXOGENOUS ATP UPON INOSITOL PHOSPHATE PRODUCTION, CATIONIC FLUXES AND INSULIN RELEASE IN PANCREATIC-ISLET CELLS [J].