EVALUATION OF (2S,4S)/(2R,4R) AND (2S,4R)/(2R,4S) 6,6-N,N-DIMETHYL-2-METHYL-2-OXO-1,3-DIOXA-4-HEXADECYL-6-AZA-2-PHOSPHACYCLOOCTANE BROMIDE AS INHIBITORS FOR PROTEIN-KINASE-C, CARNITINE OCTANOYLTRANSFERASE, AND CARNITINE PALMITOYLTRANSFERASE

被引：6

作者：

KUMARAVEL, G

ABHAIRD, NN

FRONCZEK, FR

RAMSAY, RR

ASHENDEL, CL

GANDOUR, RD

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM BIOPHYS,SAN FRANCISCO,CA 94143

[3] DEPT VET AFFAIRS MED CTR,DIV MOLEC BIOL,SAN FRANCISCO,CA 94121

[4] LOUISIANA STATE UNIV,DEPT CHEM,BATON ROUGE,LA 70803

[5] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM,W LAFAYETTE,IN 47907

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80256-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(2S,4S)/(2R,4R) and (2S,4R)/(2R,4S) 6,6-N,N-dimethyl-2-methyl-2-oxo-1,3-dioxa-4-hexadecyl-6-aza-2-phosphacyclooctane bromide strongly inhibited protein kinase C and moderately inhibited carnitine octanoyltransferase and carnitine palmitoyltransferase.

引用

页码：883 / 886

页数：4

共 14 条

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