MUTATION POSITION AND TYPE OF SUBSTITUTION IN THE BETA-SUBUNIT OF THE RNA-POLYMERASE INFLUENCE IN-VITRO ACTIVITY OF RIFAMYCINS IN RIFAMPICIN-RESISTANT MYCOBACTERIUM-TUBERCULOSIS

被引：105

作者：

BODMER, T

ZURCHER, G

IMBODEN, P

TELENTI, A

机构：

[1] Institute for Medical Microbiology, University of Berne

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 35卷 / 02期

关键词：

D O I：

10.1093/jac/35.2.345

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Quantitative susceptibility testing for rifampicin, rifabutin and rifapentine of 36 Mycobacterium tuberculosis isolates with known sequences for the gene encoding for the RNA polymerase beta-subunit (rpoB) revealed that both mutation position and type of amino acid substitution influence the in-vitro activity of rifamycins in rifampicin-resistant strains.

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页码：345 / 348

页数：4

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