PARENTAL SMOKING, URINARY COTININE, AND WHEEZING BRONCHITIS IN CHILDREN

被引：54

作者：

RYLANDER, E

PERSHAGEN, G

ERIKSSON, M

BERMANN, G

机构：

[1] Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm

[2] Department of Pediatrics, St. Göran’s Hospital and Karolinska Institute, Stockholm

[3] Department of Environmental Health and Infectious Diseases Control, Karolinska Hospital, Stockholm

来源：

EPIDEMIOLOGY | 1995年 / 6卷 / 03期

关键词：

ASTHMA; BIOMARKER; BRONCHITIS; CASE CONTROL STUDY; CHILDREN; COTININE; ENVIRONMENTAL TOBACCO SMOKE (ETS); PARENTAL SMOKING; WHEEZING;

D O I：

10.1097/00001648-199505000-00017

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We conducted a case control study to assess the role of exposure to environmental tobacco smoke (ETS) in the development of wheezing bronchitis in children. The study included 199 children age 4 months to 4 years, who were treated in hospital for wheezing bronchitis, and 351 population controls of the same age group. We estimated exposure to ETS from urinary cotinine measurements as well as from questionnaires to parents. The median urinary cotinine concentration was 5.7 mu g per liter in cases and 4.4 mu g per liter in controls. Breast-feeding was related to urinary cotinine excretion in children with smoking mothers. The risk of wheezing bronchitis in creased in relation to parental smoking and urinary cotinine concentration. This effect was most prominent in children up to 18 months of age, among whom the relative risk was 3.3 in those with a urinary cotinine level exceeding 20 mu g per liter (95% confidence interval = 1.5-7.6). Our data confirm that ETS is an important risk factor for wheezing bronchitis in children and indicate that a single urinary cotinine measurement offers no major advantages to questionnaire data for assessment of long term exposure to ETS.

引用

页码：289 / 293

页数：5

共 29 条

[1]

Skoner D., Caliguiri L., The wheezing infant, Pediatr Clin North Am, 35, (1988)

[2]

Fergusson D.M., Horwood L.J., Shannon F.T., Taylor B., Parental smoking and lower respiratory illness in the first three years of life, J Epidemiol Community Health, 35, pp. 180-184, (1981)

[3]

Palmieri M., Longobardi G., Napolitano G., Simonetti D.M.L., Parental smoking and asthma in childhood, Eur J Pediatr, 149, pp. 738-740, (1990)

[4]

Wright A., Holherg C., Martinez F., Taussig L., Relationship of parental smoking to wheezing and non-wheezing lower respiratory tract illnesses in infancy, J Pediatr, 118, pp. 207-214, (1991)

[5]

Greenberg R., Haley N., Etzel R., Loda F., Measuring the exposure of infants to tobacco smoke, N Engl J Med, 310, pp. 1075-1078, (1984)

[6]

Wall M., Johnson J., Jacob P., Benowitz N., Cotinine in the serum, saliva and urine of nonsmokers, passive smokers and active smokers, Am J Public Health, 78, pp. 699-701, (1988)

[7]

Jarvis M.J., Application of biochemical intake markers to passive smoking measurement and risk estimation, Mutation, 222, pp. 101-110, (1989)

[8]

Chilmonczyk B., Knight G., Palomaki G., Pulkkinen A., Williams J., Haddow J., Environmental tobacco smoke exposure during infancy, Am J Public Health, 80, pp. 1205-1208, (1990)

[9]

Willers S., Attewell R., Bensryd I., Schutz A., Skarping G., Vahter M., Exposure to environmental tobacco smoke in the household and urinary cotinine excretion, heavy metals retention, and lung function, Arch Environ Health, 47, pp. 357-363, (1992)

[10]

Luck W., Nau H., Nicotine and cotinine concentrations in serum and urine of infants exposed via passive smoking or milk from smoking mothers, J Pediatr, 107, pp. 816-820, (1985)

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