共 12 条
RAPID HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY OF ETHYNYLOESTRADIOL IN RABBIT PLASMA
被引:15
作者:

FERNANDEZ, N
论文数: 0 引用数: 0
h-index: 0
机构: Department of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of León

GARCIA, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Department of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of León

DIEZ, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Department of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of León

TERAN, MT
论文数: 0 引用数: 0
h-index: 0
机构: Department of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of León

SIERRA, M
论文数: 0 引用数: 0
h-index: 0
机构: Department of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of León
机构:
[1] Department of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of León
来源:
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS
|
1993年
/
619卷
/
01期
关键词:
D O I:
10.1016/0378-4347(93)80458-G
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
A method for the determination of ethynyloestradiol in samples of rabbit plasma containing pentobarbital and heparin, the former used as an anaesthetic and the latter as an anticoagulant, has been developed. Quantification was carried out using a reversed-phase high-performance liquid chromatographic (HPLC) method in isocratic mode at room temperature, with electrochemical detection at an applied potential of +1 V vs. Ag/AgCl. Under these conditions, the retention time for ethynyloestradiol was ca. 2.9 min, the average recovery from plasma was 74.5%, and the limit of detection was 10 pg, corresponding to a plasma concentration of 50 pg/ml using 1 ml of plasma. Natural oestrogens, oestriol, oestradiol and oestrone showed peaks that did not interfere with ethynyloestradiol, and retention times of ca. 0.8, 2.4 and 3.4 min, respectively.
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页码:143 / 147
页数:5
相关论文
共 12 条
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