IMPACT OF INFECTION BY HELICOBACTER-PYLORI ON THE RISK AND SEVERITY OF ENDEMIC CHOLERA

被引：62

作者：

CLEMENS, J

ALBERT, MJ

RAO, M

QADRI, F

HUDA, S

KAY, B

VANLOON, FPL

SACK, D

PRADHAN, BA

SACK, RB

机构：

[1] INT CTR DIARRHOEAL DIS RES,DHAKA,BANGLADESH

[2] UNIV MARYLAND,CTR BIOTECHNOL,BALTIMORE,MD

[3] JOHNS HOPKINS UNIV,SCH PUBL HLTH,BALTIMORE,MD

[4] CTR DIS CONTROL & PREVENT,ATLANTA,GA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 06期

关键词：

D O I：

10.1093/infdis/171.6.1653

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate the relationship between Helicobacter pylori infection and the subsequent risk and severity of endemic Vit,rio cholerae O1 diarrhea among rural Bangladeshis, 285 children and adults with cholera (cases) and 881 contemporaneously selected community controls were studied. Cases and controls were contrasted for H, pylori infection, as manifested by serum IgG anti-H. pylori antibodies, Although the overall risk of cholera was not significantly increased among H. pylori-infected subjects, the risk of cholera of life-threatening severity was signifi::cantly elevated (relative risk [RR] = 1.61; 95% confidence interval [CI] = 1.07-2.42), A significant increase in the risk of severe cholera was seen in subjects who lacked natural serum vibriocidal antibodies (RR = 2.88; 95% CI = 1.28-6.48) but not in those with such antibodies. Thus, H. pylori infection was associated with a significant increase in the risk of life-threatening cholera, but only among persons lacking natural vibriocidal immunity.

引用

页码：1653 / 1656

页数：4

共 15 条

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