FEVER IN UNCOMPLICATED PLASMODIUM-FALCIPARUM INFECTION - EFFECTS OF QUININE AND PARACETAMOL

被引：16

作者：

KRISHNA, S

SUPANARANOND, W

PUKRITTAYAKAMEE, S

TERKUILE, F

SUPPUTAMANGKOL, Y

ATTATAMSOONTHORN, K

RUPRAH, M

WHITE, NJ

机构：

[1] MAHIDOL UNIV,FAC TROP MED,BANGKOK 10400,THAILAND

[2] JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND

[3] PAHOLPOLPAYUHASENA HOSP,KANCHANABURI,THAILAND

[4] POISONS UNIT,LONDON SE14 5ER,ENGLAND

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 89卷 / 02期

基金：

英国惠康基金;

关键词：

MALARIA; PLASMODIUM FALCIPARUM; TREATMENT OF FEVER;

D O I：

10.1016/0035-9203(95)90494-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The effects of quinine and paracetamol on fever were studied in 21 adult patients with acute uncomplicated falciparum malaria. Quinine alone (n=7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n=7) or 2 h before quinine (n=7) reduced temperature by a mean of 2.1 degrees C (standard deviation [SD] 0.95) and 2.1 degrees C (SD 0.79) respectively. A temperature reduction of 1 degrees C was associated with a mean decrement of 9.7 beats/min (SD 3.3) in the pulse rate. Quinine does not possess useful antipyretic activity.

引用

页码：197 / 199

页数：3

共 6 条

[1] FEVER RESPONSES TO BACTERIAL PYROGENS IN GUINEA PIGS AND APPLICATION FOR SCREENING OF ANTIPYRETIC AGENTS [J].