NEUROPEPTIDE MESSENGER PLASTICITY IN THE CNS NEURONS FOLLOWING AXOTOMY

被引：38

作者：

PALKOVITS, M ^{[1
]}

机构：

[1] NIMH,CELL BIOL LAB,BETHESDA,MD 20892

来源：

MOLECULAR NEUROBIOLOGY | 1995年 / 10卷 / 2-3期

关键词：

NEUROPEPTIDES; NEUROPEPTIDE MESSENGER-RNA; AXOTOMY; CENTRAL NERVOUS SYSTEM; NEURONAL PLASTICITY;

D O I：

10.1007/BF02740669

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal peptides exert neurohormonal and neurotransmitter (neuromodulator) functions in the central nervous system (CNS). Besides these functions, a group of neuropeptides may have a capacity to create cell proliferation, growth, and survival. Axotomy induces transient (1-21 d) - upregulation of synthesis and gene expression of neuropeptides, such as galanin, corticotropin releasing factor, dynorphin, calcitonin gene-related peptide, vasoactive intestinal polypeptide, cholecystokinin, angiotensin II, and neuropeptide Y. These neuropeptides are colocalized with ''classic'' neurotransmitters (acetylcholine, aspartate, glutamate) or neurohormones (vasopressin, oxytocin) that are downregulated by axotomy in the same neuronal cells. It is more likely that neuronal cells, in response to axotomy, increase expression of neuropeptides that promote their survival and regeneration, and may downregulate substances related to their transmitter or secretory activities.

引用

页码：91 / 103

页数：13

共 48 条

[1] SELECTIVE UP-REGULATION OF NEUROPEPTIDE SYNTHESIS BY BLOCKING THE NEURONAL-ACTIVITY - GALANIN EXPRESSION IN SEPTOHIPPOCAMPAL NEURONS [J].