REVERSION OF THE MOUSE PINK-EYED UNSTABLE MUTATION INDUCED BY LOW-DOSES OF X-RAYS

被引：77

作者：

SCHIESTL, RH

KHOGALI, F

CARLS, N

机构：

[1] Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115

来源：

SCIENCE | 1994年 / 266卷 / 5190期

关键词：

D O I：

10.1126/science.7985029

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Deletions and other genome rearrangements can be caused by radiation and are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (p(un)) mutation in the mouse is caused by a gene duplication and reverts to wild type by deletion of one copy. Reversion events in the mouse embryo were detected as black spots on the fur of the animals or microscopically as partially black hair in a background of colorless hair. The frequency of partially black hair was increased by x-rays at very low doses. A linear dose-response relation was found between 1 and 100 centigray.

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页码：1573 / 1576

页数：4

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