DETERMINATION OF BOLDINE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：26

作者：

SPEISKY, H

CASSELS, BK

NIETO, S

VALENZUELA, A

NUNEZVERGARA, LJ

机构：

[1] UNIV CHILE,FAC CIENCIAS,DEPT QUIM,SANTIAGO,CHILE

[2] UNIV CHILE,FAC CIENCIAS QUIM & FARMACEUT,FARMACOL LAB,SANTIAGO,CHILE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 612卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80179-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive method for the determination of boldine in blood plasma is described. The procedure involves a direct pH-buffed chloroform extraction of boldine from blood plasma, followed by its assay under isocratic conditions by HPLC with UV detection. The extraction recovery is excellent, and sensitivity and precision of the method are very high, when applied to plasma samples containing pharmacologically relevant concentrations of boldine.

引用

页码：315 / 319

页数：5

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