INHIBITION OF NITRIC-OXIDE SYNTHASE - POTENTIAL FOR A NOVEL CLASS OF THERAPEUTIC AGENT

被引：79

作者：

OGDEN, JE

MOORE, PK

机构：

[1] Propharma Consultants, Nottingham

[2] The Pharmacology Group, Biomedical Sciences Division, King's College, London, SW3 6LX, Manresa Road

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0167-7799(00)88908-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The free-radical gas nitric oxide (NO) plays an important role in a wide and diverse range of physiological processes. As progress is made in understanding the biological function of NO, there is growing interest in the possibility that inhibitors of NO synthase (NOS) may be of clinical use in the therapy of certain disease states. The search for novel and clinically relevant inhibitors of this enzyme represents a truly multidisciplinary approach to drug screening and will no doubt benefit from the application of recombinant DNA (rDNA) technology.

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页码：70 / 78

页数：9

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