EFFECTS OF PROSTAGLANDIN E(2) ON THE MICRONUCLEUS FORMATION IN MOUSE BONE-MARROW CELLS BY VARIOUS MUTAGENS

被引：5

作者：

SUZUKI, Y

SHIMIZU, H

ISHIKAWA, T

SAKABA, H

FUKUMOTO, M

OKONOGI, H

KADOKURA, M

机构：

[1] Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Minato-Ku, Tokyo, 105

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1994年 / 311卷 / 02期

关键词：

MICRONUCLEI; ERYTHROPOIESIS; PROSTAGLANDIN E(2); ERYTHROBLAST;

D O I：

10.1016/0027-5107(94)90187-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effects of prostaglandin E(2) (PGE(2)), as a trigger of erythroid progenitor cells into the cell cycle, were studied on the induction of micronuclei by various mutagens; with mitomicin C (MMC) the optimal protocol was established. PGE(2) itself did not induce any micronuclei in this experiment. The highest frequency of micronuclei and dose-response relationship between PGE(2) doses and micronucleus frequency were observed 30 h after injection of MMC to mice administered PGE(2) 24 h previously. Sensitization by PGE(2) pretreatment was also found for other mutagens, such as vincristine, 5-fluorouracil, benzo[a]pyrene, 1,1-dimethylhydrazine and 2-naphthylamine. These results support the hypothesis that accelerating the erythropoiesis increases the frequency of micronuclei induced by mutagens.

引用

页码：287 / 293

页数：7

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