KARYOTYPE ANALYSIS OF VIRULENT PLASMODIUM-FALCIPARUM STRAINS PROPAGATED IN SAIMIRI-SCIUREUS - STRAIN ADAPTATION LEADS TO DELETION OF THE RESA GENE

被引：6

作者：

HINTERBERG, K

MUANZA, K

HERNANDEZRIVAS, R

GAY, F

GYSIN, J

MATTEI, D

SCHERF, A

机构：

[1] INST PASTEUR,UNITE PARASITOL EXPTL,CNRS,URA 361,F-75724 PARIS 15,FRANCE

[2] GRP HOSP PITIE SALPETRIERE,DEPT MALAD INFECT PARASITAIRES TROP & SANTE PUBL,INSERM,U313,F-75013 PARIS,FRANCE

[3] INST PASTEUR,UNITE PARASITOL EXPTL,F-69210 LENTILLY,FRANCE

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 02期

关键词：

D O I：

10.1128/IAI.63.2.693-695.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The squirrel monkey, Saimiri sciureus, is an important experimental model for the study of the human malaria parasite Plasmodium falciparum. A detailed karyotype analysis of four different P. falciparum strains propagated in S. sciureus was done using various subtelomeric antigen gene probes. We observed deletion of the complete RESA gene from chromosome I in all four strains. Interestingly, a loss of RESA was observed immediately upon adaptation to the squirrel monkey, suggesting that this DNA rearrangment is fundamental for the P. falciparum infection of S. sciureus erythrocytes. However, a RESA-specific gene probe hybridized with chromosome 1 of wild isolates from 28 different patients, indicating that this gene is maintained during infection of humans.

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页码：693 / 695

页数：3

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