BENOMYL - NOVEL TYPE OF BASE ANALOG MUTAGEN/N

被引：35

作者：

KAPPAS, A ^{[1
]}

GREEN, MHL ^{[1
]}

BRIDGES, BA ^{[1
]}

ROGERS, AM ^{[1
]}

MURIEL, WJ ^{[1
]}

机构：

[1] UNIV SUSSEX, MRC, CELL MUTATION UNIT, BRIGHTON BN1 9QG, SUSSEX, ENGLAND

来源：

MUTATION RESEARCH | 1976年 / 40卷 / 04期

关键词：

D O I：

10.1016/0165-1218(76)90036-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenic action of benomyl, a benzimidazole derivative widely used as a systematic fungicide, was tested against several bacterial strains. Tryptophan requiring Escherichia coli WP2 and histidine requiring Salmonella typhimurium TA1535 and TA1538 were used. The WP2 strains and TA1535 respond to base-pair mutagens and TA1538 to frameshift mutagens. Significant mutagenesis was observed in WP2 and TA1535 strains but not in TA1538, indicating that benomyl acts by being incorporated into DNA, but once incorporated, it is seen by the cell as a non-pairing purine with a large alkyl or aryl group attached.

引用

页码：379 / 382

页数：4

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