ABSORPTION AND DISPOSITION OF COLLOIDAL DRUG DELIVERY SYSTEMS .1. HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC (HPLC) ANALYSIS OF A CYCLOSPORINE EMULSION

被引：8

作者：

CORVARI, SJ ^{[1
]}

HOLLENBECK, RG ^{[1
]}

LESLIE, J ^{[1
]}

PLAISANCE, KI ^{[1
]}

YOUNG, D ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH PHARM,DEPT PHARMACEUT,CLIN PHARMACOKINET LAB,20 N PINE ST,BALTIMORE,MD 21201

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 01期

关键词：

EMULSION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC); CYCLOSPORINE; DRUG DELIVERY;

D O I：

10.1023/A:1015870020952

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The amount of cyclosporin A in an oil-in-water emulsion drug delivery system was determined by HPLC. The direct extraction and analysis of an intact emulsion were compared to the analysis of a cracked emulsion and an olive oil solution of the drug. The intra- and interday variability for the intact emulsion was less than 10% from 35 to 150-mu-g/ml, with recovery of 94%. Comparison of the assay results obtained with the emulsion and the olive oil solution gave a highly correlated regression line with a small intercept and a slope close to unity. Thus, the direct extraction and HPLC analysis of drugs in emulsions may be a viable approach to evaluate drug content.

引用

页码：40 / 42

页数：3

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